sheng lab broad institute

University of Minnesota 4.2. his work to improve single-cell research protocols and technologies and how he transitioned from dentistry to life in a lab.Read more . Her group has expertise in the physiology of ion channels, part of the large protein family critical to neurons firing and muscles moving. In March of 2020, Broad Institute converted a clinical genetics processing lab into a large-scale COVID-19 testing facility in less than two weeks. Sheng completed his medical training and a residency in general medicine in London, UK. Sheng Ding, PhD Senior Investigator, Gladstone Institutes . Broad Genomics Platform sequences a whole human genome every four minutes. All Broad employees, regardless of work location, must be fully vaccinated for COVID-19 by Tuesday, October 12, 2021. Category: research Scientists at Fralin Biomedical Research Institute develop new strategy for brain cancer treatment. Characterised the role of JNK signaling in posterior regeneration . Our research is mainly focused on the RNA chemical modification and RNA structure biology. Every summer, 18 high school students spend six weeks at Broad working side-by-side with mentors on cutting-edge research. More than 11,000 individuals living with cancer in the United States and Canada have partnered with Count Me In to share their experiences and help accelerate cancer research. Just another site. 43 Vassar Street, Bldg. Isotianil is a monocarboxylic acid amide that has been used as a fungicide to control rice blast and could potentially induce systemic . In 2021, our sustainability efforts sent more than 80 percent of waste from the Genomics Platform to either a recycling facility or to an incineration plant that generates electricity. Broad Genomics Platform sequences a whole human genome every four minutes. The labhas used a broad range of approaches to tackle these problems, notably the development of neuronal cultures from adult disease mouse models and live imaging of various organelle transport. Sheng is a fellow of the Royal Society (UK), a fellow of the Academy of Medical Sciences (UK), a fellow of the American Association for the Advancement of Science, and honorary fellow of Corpus Christi College, Oxford. The impact of Shengs research has been recognized by several prizes including the Fondation IPSEN Prize for Neuronal Plasticity and the Society for Neurosciences Young Investigator Award. AY Hung, M Sheng. Visit our free public educational space that showcases how researchers at the Broad and their colleagues around the world seek to understand and treat human disease. Based on the above information, the Hydrus-2D model was established, then the study area was Jo ur na l P re -p ro of Journal Pre-proof 12 discretized and . Neuron 29 (2), 353-366, 2001. . Cambridge, MA 02142 (Kendall Square area) Full-time. Novozym 435 showed to be stable up to 80 C in the packed-bed microreactor, with low reactant molar ratio (ethyl butyrate:1-butanol) being desirable to achieve higher conversions. We've screened more than 1,275 cancer cell lines as part of the Cancer Dependency Map (DepMap). Work with wet-lab biologists to design and implement appropriate experiments for future computational analysis in areas such as neurophysiology and behavior. During his Ph.D., he . Morgan Sheng, a neurobiologist and physician-scientist with deep experience in both basic research and drug discovery, has joined the Broad Institute of MIT and Harvard as its newest Core Member and as Co-Director of the institutes Stanley Center for Psychiatric Research. Feng Laboratory McGovern Institute For Brain Research 43 Vassar Street, Office: 46-3133 Cambridge, Massachusetts 02139 Phone: (617) 715-4920 Website: fenglaboratory.org. Meet our members, staff scientists, fellows and other Broadies. 2018 Dec 19;100(6):1322-1336.e7. Categories . He obtained his B.S. Shengs molecular studies of the structure and function of synapses (the communication junctions between brain cells) while at MGH and MIT have enhanced our understanding of the neural basis of cognitive function and dysfunction, including learning and memory, neurodevelopmental disorders, and dementia. From 2008 to 2019, Sheng was Vice-President of Neuroscience at Genentech, a leading biotech company, where he led research and drug discovery efforts for major diseases of the nervous system. The NeuroGAP-Psychosis project, a collaboration between the Stanley Center for Psychiatric Research and Harvard T.H. Morgan Sheng, a neurobiologist and physician-scientist with deep experience in both basic research and drug discovery, has joined the Broad Institute of MIT and Harvard as its newest Core Member and as Co-Director of the institute's Stanley Center for Psychiatric Research. My research will involve a combination of organic synthesis, microbiology, molecular biology, enzymology, and potential optimization of . Dr. Sheng received his Ph.D. in Biochemistry from the University of Pennsylvania in 1993. This center is developing new paradigms and technologies to scale the discovery of biological mechanisms of common, complex diseases, by facilitating close collaborations between the Broad Institute and the Danish research community. He is affiliated with the Department of Electrical and Computer Engineering, Carle Illinois College of Medicine, Beckman Institute, and the Department of Bioengineering. sweet things to write in a baby book. Apply Now Job Salary Company Rating Job Description The Broad Institute of MIT & Harvard is looking for outstanding postdoctoral scholars to join the laboratory of Morgan Sheng, Co-Director of the Stanley Center for Psychiatric Research Matt received a Ph.D. in Chemical Engineering from the University of Maryland in 2001. Ph.D. in neuroscience, molecular/cellular biology, biochemistry, computational biology, or related field, Completion of at least one research project as evidenced by one or more first author research articles published or submitted to a well-recognized peer-reviewed journal. Blainey Lab Golub Lab Hung Lab Lander Lab Liu Lab Regev Lab Schreiber Lab Sellers Lab Xavier Lab Zhang Lab Institute Member labs Eric Alm, MIT Paola Arlotta, Harvard Picower Professor of Biology and Neuroscience; Director, RIKEN-MIT Laboratory for Neural Circuit Genetics. Basic laboratory methods of molecular cell biology, imaging, and/or electrophysiology, Self-motivation and rigorousness in experimental research, Excellent communication skills (written and oral), Ability to work independently and interact cooperatively with others, Expertise in computational/bioinformatics approaches to biological problems, Experience of data-rich experimental techniques, such as single cell RNAseq, ATACseq, MS proteomics, functional genomic screens, high content imaging. far beyond the soil depth of 100-200 cm in other lab-column or on-site studies (Sheng et al., 2021). ; 2 Department of Microbiology, Li Ka Shing, Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China. Dr. Sheng Lin-Gibson is the Chief of the Biosystems and Biomaterials Division (BBD) at the National Institute of Standards and Technology (NIST). Currently, the Sheng lab focuses on three areas of research: Immune response to infection and vaccination: We develop computational methods to study immune responses . sheng lab broad institute. Using genetic mouse models, his group is addressing several fundamental questions: (1) how mitochondrial transport is regulated to sense changes in synaptic activity, mitochondrial integrity, axon injury and pathological stress; (2) how neurons coordinate late endocytic transport and autophagy-lysosomal function to maintain cellular homeostasis and distal degradation capacity; (3) how impaired transport contributes to synaptic dysfunction and axonal pathology in neurodegenerative diseases. Copyright 2008-2023, Glassdoor, Inc. "Glassdoor" and logo are registered trademarks of Glassdoor, Inc, The Broad Institute of MIT & Harvard is looking for outstanding postdoctoral scholars to join the laboratory of Morgan Sheng, Co-Director of the. 32. Discover remarkable stories of scientific progress, and explore the intersections of science, medicine, and society. We are at a critical point where genetic and biological insights are emerging that can transform the way we study, diagnose, and treat mental illness. Postdoctoral Fellow, Laboratory of Steven McCarroll, Harvard Medical School and Broad Institute of MIT and Harvard. Postdoctoral Associate - Sheng Lab Broad Institute of MIT and Harvard Cambridge, MA 1 month ago Be among the first 25 applicants jleonard@caltech.edu. Karam Kim University of California . The Chen Lab. . Ben joined the Engreitz Lab at the Broad Institute to develop experimental and computational tools to study enhancers and noncoding GWAS variants at single-cell resolution. Morgan Sheng Email: Postdoc 1990-1994: Co-Director of Stanley Center for Psychiatric Research, MIT Broad Institute: Website: George Lopez Email: Graduate Student 1989-1995: Associate Professor, Rush University: Website: Dan Doherty . Broad Institute 4.0. . Find your next job opportunity near you & 1-Click Apply! You can contact the company at 02 2245 3355.You can find more information about at www.sl-lab.com.tw. Cambridge, MA 02142. More than 11,000 individuals living with cancer in the United States and Canada have partnered with Count Me In to share their experiences and help accelerate cancer research. Kingston, Ontario, Canada. Affiliations. 617-714-7021. The Stanley Center aims to reduce the burden of serious mental illness by contributing new insights into pathogenesis, identifying biomarkers, and paving the way toward new treatments. He is also a professor of neuroscience in MITs Department of Brain and Cognitive Sciences, and an affiliate of both the McGovern Institute for Brain Research and the Picower Institute for Learning and Memory. See popular questions & answers about Broad Institute; Post-Doctoral Associate - Neuroscience Department. Morgan Sheng is a core institute member of the Broad Institute of MIT and Harvard, where he serves as co-director of the Broads Stanley Center for Psychiatric Research. Lab Website molbiolabs.princeton.edu/cristea ; 3 NHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen . Oana Ursu Status: Postdoc, Aviv Regev lab, Broad Institute Lab Affiliation: PhD, Genetics Dept., Co-advised by Mike Snyder Sept 2013 - Mar 2018 (HHMI International Fellow) Research focus: 3D genome organization, enhancer-gene linking, regulatory . A multimodal molecular cell-type atlas of the MOp. Structural Insights of Non-canonical U-U Pair and Hoogsteen Interaction Probed with Se Atom. He has served on the editorial boards of, Presidential Early Career Award for Scientists and Engineers, Young Investigator Award, Society for Neuroscience (1999), President, Society of Chinese Neuroscientists of America (2001-2003), Fellow of the American Association for the Advancement of Science (AAAS) (elected Sept 2004). The broad conservation of plant microbiota suggests that plants . From 2008 to 2019, Sheng was Vice-President of Neuroscience at Genentech, a leading biotech company, where he led research and drug discovery efforts for major diseases of the nervous system. Queen's University. We are seeking a motivated Computational Associate II (CA) to join the Sheng Lab at the Broad Institute of MIT and Harvard. Ma Huang (Ephedrae Herba) 9 g, Zhi Gan Cao (Glycyrrhizae Radix) 6 g, Xing Ren (Armeniacae Semen) 9 g, Sheng Shi Gao (Gypsum fibrosum . Borislav Dejanovic, PhD (Staff Scientist/ Group Leader, Broad Institute), Sarah Wade (Research Associate, Broad Institute), Core Institute Member, Broad Institute of MIT and Harvard, Co-Director of the Stanley Center for Psychiatric Research at the Broad Institute, Office: Broad Institute, 75 Ames St. Room 9023. Compositions and Methods for Conversion of Aldehydes to Alkanes (2011) Weiqing Zeng and Sheng Yang He. Key scientific datasets and computational tools developed by our scientists and their collaborators. A cleaning revolution: How JCS-Echigo partnered A*STAR to clean faster and smarter. Postdoctoral Associate - Sheng Lab Broad Institute of MIT and Harvard Cambridge, MA 1 month ago Be among the first 25 applicants Director, Cornell Institute of BiotechnologyDirector, Center for Life Science Enterprise. In 2021, our sustainability efforts sent more than 80 percent of waste from the Genomics Platform to either a recycling facility or to an incineration plant that generates electricity. Learn about Broad Institute's mentored research offerings for high school students, college students, and recent college graduates. Excited & proud to share the work of #PeijunMa, a longtime friend & collaborator who led (in #DebHung 's lab . +1 415 734-2717. Chemical biology and therapeutics science, Genome regulation, cellular circuitry, and epigenomics, Merkin Institute for Transformative Technologies in Healthcare, Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Several pre-existing RSV lineages powered the 2022 surge, Blood stem cells are susceptible to ferroptosis, a type of cell death, Rare genetic variants can reveal much about disease biology, Researchers map brain cell changes in Alzheimers disease. Morgan Sheng Co-Director of the Stanley Center for Psychiatric Research at the Broad Institute; Professor of Neuroscience, Department of Brain and Cognitive Sciences, MIT Bipolar Disorder and Schizophrenia: from human genetics towards neurobiological mechanisms Susan Dymecki Professor of Genetics, Harvard Medical School Todd McDevitt, PhD Senior Investigator, Gladstone Institutes . Morgan Sheng is a core institute member of the Broad Institute of MIT and Harvard, where he serves as co-director of the Broads Stanley Center for Psychiatric Research. He completed his postdoctoral research with William Catterall at the University of Washington in 1996. Research. Postdoctoral Associate - Xavier Lab: Broad Institute: Cambridge, MA: Post Doc Researcher - Social Media - Microsoft Research: Microsoft: Cambridge, MA: Postdoctoral fellow - Computational genetics and Genomics: Brigham & Women's Hospital(BWH) Boston, MA: Postdoctoral Associate - Sheng Lab: Broad Institute: Cambridge, MA Bio: Dr. Innis's laboratory uses novel positron emission tomography (PET) radioligands to measure neuroinflammation in volunteers with Alzheimer's disease and other dementias. Mechanisms regulating axonal organelle transport in healthy and diseased neurons. From 2001 to 2008, Sheng was the Menicon Professor of Neuroscience at MIT, as well as an investigator of the Howard Hughes Medical Institute. Our study identifies LSD1 as a potent inhibitor of anti-tumor immunity and responsiveness to immunotherapy and suggests LSD1 inhibition combined with PD- (L)1 blockade as a novel cancer treatment strategy. Howard Hughes Medical Institute, Duke University, Durham, NC, USA . The mechanisms of chemical reactions, including the transformation pathways of the electronic and geometric structures of molecules, are crucial for comprehending the essence and developing new chemistry. is located in Taipei. A past recipient of the Fondation Ipsen Prize in Neuronal Plasticity and the Young Investigator Award of the Society for Neuroscience, Sheng received a B.A. Mackenzie Abbott. From 2001 to 2008, Sheng was the Menicon Professor of Neuroscience at MIT, as well as an investigator of the Howard Hughes Medical Institute. Nonhematopoietic cells, including epithelial cells and stromal cells, are also important for enhancing or dampening inflammatory immune responses, especially at "barrier sites" such as the gastrointestinal (GI) tract and skin. Research Scientist I - Therapeutics Group - Sheng Lab. In Situ Biology Join Us Contact The Chen Lab. Morgan Sheng, a neurobiologist and physician-scientist with deep experience in both basic research and drug discovery, has joined the Broad Institute of MIT and Harvard as its newest Core Member and as Co-Director of the institute's Stanley Center for Psychiatric Research.He will also return to MIT, after a decade in industry, as a professor of neuroscience in the Department of Brain and . Yeh FL, Wang Y, Tom I, Gonzalez LC, Sheng M. Neuron 2016 Jul 20;91(2):328-40. Phone. Find out how to join the Broad as an employee or associate member. Correlating atomic configurationsspecifically, degree of disorder (DOD)of an amorphous solid with properties is a long-standing riddle in materials science and condensed matter physics . By the end of 2022, Broads COVID-19 testing lab had processed more than 37 million tests. The successful candidate will join a multidisciplinary group and perform cutting-edge basic and/or translational research on the molecular, cellular and . Job functions Engineering, Information Technology, Operations. Morgan Sheng, a neurobiologist and physician-scientist with deep experience in both basic research and drug discovery, has joined the Broad Institute of MIT and Harvard as its newest Core Member and as Co-Director of the institute's Stanley Center for Psychiatric Research.He will also return to MIT, after a decade in industry, as a professor of neuroscience in the Department of Brain and . Synthesis of novel probes to identify and characterize polymer-degrading enzymes. From 2001 to 2008, Sheng was the Menicon Professor of Neuroscience at MIT, as well as an investigator of the Howard Hughes Medical Institute. We work closely with pharmaceutical, biotech, and technology partners to accelerate the translation of our discoveries. biology .mit .edu. 10 The Xpert test has shown both accurate performance in . Our researchers use their expertise in creating, adapting, and applying a variety of technologies to enable science here and beyond. Through programs spanning genetics, biology, and therapeutic development, Broad researchers are making discoveries that drive biomedical science forward. From 2008 to 2019, Sheng was Vice-President of Neuroscience at Genentech, a leading biotech company, where he led research and drug discovery efforts for major diseases of the nervous system. The address is No. https://doi.org/10.1038/s41593-022-01251-x. Moderated by MIT and Broad Institute Professor Morgan Sheng. Nature neuroscience 12 (4), 428-437, 2009. . Lab Affiliation: Postdoctoral Associate Mar 2016 - Dec 2016. Faculty Assistant Mary Gidaro mgidaro@princeton.edu 105 Thomas Laboratory p 609-258-8956 f 609-258-1704. 1 Broad Institute of MIT and . Email. He/she would address fundamental scientific questions, formulate hypotheses, design and execute experiments, interpret data, and write and publish original papers, often in teamwork with other lab members and external collaborators. The Gerstner Center is developing next-generation diagnostic technology for cancer detection and tracking disease progression. (+1) 617-452-2588. The McGovern Institute is an integral part of MIT with a board that includes representatives appointed by the McGovern family and by MIT. The Broad faculty consists of Institute Members and Associate Members. SPANGLER LAB. Merkin Building and sequencing, takes ~3 d to process up to 192 samples manually. He obtained his B.S. A catalog of scientific papers published by our members and staff scientists. About the Lab. The Xpert HIV-1 qualitative assay (Xpert HIV-1 Qual; Cepheid, Sunnyvale, CA, USA) for early infant diagnosis is considered to be a point-of-care test according to the REASSURED criteria; 9 although it takes 90 min, the assay is able to provide results on the same day as testing. fayetteville state basketball; Tags . . Postdoctoral Associate - Sheng Lab. He completed his Ph.D. in 2016 at the Wellcome Trust Sanger Institute, where he studied the role of rare variation in the genetic architecture of psychiatric and neurodevelopmental disorders. Check out this video for a look into our community! Dr. Sheng received his Ph.D. in Biochemistry from the University of Pennsylvania in 1993. Broad brings people together to advance the understanding and treatment of disease. His work has uncovered the form and complexity of protein complexes in the postsynaptic membrane that regulate the remarkable plasticity of neuronal connections. His Ph.D. thesis was completed at Harvard Medical School in the lab of Michael Greenberg. Avoid inappropriate use of antibacterial drugs, especially the combined use of broad-spectrum antibacterial drugs. A past recipient of the Fondation Ipsen Prize in Neuronal Plasticity and the Young Investigator Award of the Society for Neuroscience, Sheng is author of more than 200 peer-reviewed publications focused on the molecular mechanisms underlying the structure and plasticity of synapses and the molecular-cell biology of neurodegeneration. Lei received his PhD in Neuroscience under the doctoral program of "Molecular Physiology of the Brain" Nikita completed his Cognitive Science Bachelor's degree from McGill university in the spring of 2019 focusing in the fields of Neuroscience and Philosophy. M Sheng, S Smiga, A Bulfone, . Postdoctoral Associate - Sheng Lab in The Broad Institute, Inc. Cambridge, MA. Browse 59 BOSTON, MA AUTISM RESEARCH job ($35K-$108K) listings hiring now from companies with openings. , United States. Some of their efforts include multifunctional drug/agent nanocarriers for the . Shawn.Sheng@nrel.gov 303-384-7106 . A past recipient of the Fondation Ipsen Prize in Neuronal Plasticity and the Young Investigator Award of the Society for Neuroscience. Journal of Biological Chemistry 277 (8), 5699-5702, 2002. Email. Find out how to join the Broad as an employee or associate member. JR Lee, AW Dunah, M Sheng, E Kim. Read . Sheng started his academic career, centered on molecular and cellular neuroscience, in 1994 at Massachusetts General Hospital and Harvard Medical School, and later moved to MIT as the Menicon Professor of Neuroscience. Identified telomerase isoforms by integrating NGS and RACE data: Designed and performed experiments (RACE) and sequence analyses (bash). A physician and a scientist, Morgan Shengis author of more than 200 peer-reviewed publications focused on the molecular cellular biology of synapses and synaptic plasticity, and pathogenic mechanisms of neurodegenerative diseases. Cambridge, MA 02142. Morgan Sheng is a core institute member of the Broad Institute of MIT and Harvard, where he serves as co-director of the Broad's Stanley Center for Psychiatric Research. Mark Inman, MBA COO and Administrator . the broad institute of mit & harvard is looking for outstanding postdoctoral scholars to join the laboratory of morgan sheng, co-director of the stanley center for psychiatric research, the mission. The Broad Institute of MIT & Harvard is looking for outstanding postdoctoral scholars to join the laboratory of Morgan Sheng, Co-Director of the Stanley Center for Psychiatric Research, The . 4 BCS News | Fall 2020 By Rachel Donahue Lab studies the genetics underlying neural development to identify new diagnostic and therapeutic approaches for a broad range of disorders that compromise brain and organ system development. Nucleic Acids Research, 2013, 41, 10476-10487. Dany Rochefort . She oversees a multidisciplinary research portfolio that includes advanced therapies, precision medicine, synthetic biology and complex microbial systems. Fralin Biomedical Research Institute faculty conduct research in wet and dry labs in our 280,000-square-foot facilities . The Chen Lab. 2012 - 2017 Ershela Durresi, Ph.D. Medical Student, Harvard Medical School . 688 Timothy Johnson and lab technician David Rhodes for assistance in gnotobiotic system . Jin Sheng's Employment details. is author of more than 200 peer-reviewed publications focused on the molecular cellular biology of synapses and synaptic plasticity, and pathogenic mechanisms of neurodegenerative diseases. Institute of Sustainability for Chemicals, Energy and Environment (ISCE 2) Institute of High Performance Computing (IHPC) . A physician and a scientist, Morgan Sheng is author of more than 200 peer-reviewed publications focused on the molecular cellular biology of synapses and synaptic plasticity, and pathogenic mechanisms of neurodegenerative diseases. Dr. Pan has more than 15 years of experience investigating the function, molecular genetics and pharmacology of ion channels. In February of 2020 he joined the Stanley Nathaniel Goble graduated from the University of Southern California in 2021 with a major in neuroscience and minor in philosophy. Merkin Building Dr. Sheng has also servedon the editorial board of Journal of Cell Biology (JCB) and Journal of Biological Chemistry (JBC) and associate editor of Autophagy. In Situ Biology . Fusarium wilt of banana, especially Tropical Race 4 (TR4) is a major factor restricting banana production. Broad-spectrum disease resistance conferred by expression of the Pseudomonas syringae hrmA gene in plants (2001) Qingshun Li, Songhai Shen, Arthur Hunt and Sheng Yang He. The Eli and Edythe L. Broad Institute of MIT and Harvard (IPA: / b r o d /, pronunciation respelling: BROHD), often referred to as the Broad Institute, is a biomedical and genomic research center located in Cambridge, Massachusetts, United States.The institute is independently governed and supported as a 501(c)(3) nonprofit research organization under the name Broad Institute Inc., and it . Requests for exemption for medical or sincerely held religious beliefs will be considered. (1st class honors) from Oxford University and obtained his medical degree and training at London University. Sheng is an elected Fellow of the Royal Society (UK), the Academy of Medical Sciences (UK), and the AAAS. Through Broad's Scientists in the Classroom program, Broad researchers visit every 8th grade classroom in Cambridge each year to talk about genetics and evolution. - Feb 2023 - Present2 months. We are a new research lab in the Department of Chemistry and The RNA Institute within the University at Albany, State University of New York (SUNY). Distinguished Investigator and Professor at Gladstone Institute of Cardiovascular Disease, and Department of Pharmaceutical Chemistry, University of California San Francisco. He joined Cornell University in 2003 where he is currently the William L. Lewis Professor of Engineering in the Robert F. Smith School of Chemical and Biomolecular . Gong Lab. Full-time. A consensus statement from the International Liaison Committee on Resuscitation (American Heart Association, Australian and New Zealand Council on Resuscitation, European Resuscitation Council, Heart and Stroke Foundation of Canada, InterAmerican Heart Foundation . By taking the advantage of next-generation sequencing technique, he uses bioinformatics approaches to investigate features of B cell repertoires, and to study mechanisms modulating the maturation process of broadly HIV-1 neutralizing antibody lineages in humans and animal models, with the aim of finding an optimal HIV . Sheng does research in Physical Chemistry, Solid-state Chemistry and Solid . Access free classroom materials and more for STEM educators, parents, students, tutors, and others. Here, we report a single-molecule approach capable of . Access free classroom materials and more for STEM educators, parents, students, tutors, and others. in chemistry with honors from Caltech in 1999, and a Ph.D. in chemistry from The Scripps Research . 908: 46-1303 Cambridge, MA 02139 . In Situ Biology Join Us Contact The Chen Lab. Researchers anywhere can explore more than 6,000 drugs in the hub and search for possible new uses for them to jump-start new drug discovery. Shawn has a broad range of experience: mechanical and electrical system modeling and analysis; data sensing and sensor placement; signal processing; machine learning and artificial intelligence; machine defect classification and level evaluation; machine life prognosis; multi scale modeling; traditional and .